Abstract： Objective： To observe the clinical effect of Tianma Huoxue tang combined with flunarizine hydrochloride capsules for vertigo symptom due to insufficiency of cerebral blood supply. Methods：A total of 125 cases of patients with vertigo symptom due to insufficiency of cerebral blood supply were selected and divided into the control group and the observation group according to the random number table method， with 62 and 63 cases in each group respectively. The control group was given the oral administration with flunarizine hydrochloride capsules， and the observation group was additionally treated with Tianma Huoxue tang based on the treatment of the control group. The vertigo symptom scores and scores of functional scale for cervical spondylosis of vertebral artery type(FS-CSA) were compared between the two groups before and after treatment，serological indexes [platelet activating factor(PAF)，thromboxane B2(TXB2)，interleukin-8(IL-8)] and hemorheological indexes were detected in the two groups. Clinical effect and adverse reactions were evaluated. Results： The total effective rate was 95.24% in the observation group，higher than that of 82.26% in the control group，the difference being significant(P＜0.05). After treatment，vertigo degree，vertigo frequency，and scores of duration and FS- CSA in the two groups were lower than those before treatment(P＜0.05)， and vertigo degree， vertigo frequency， and scores of duration and FS-CSA in the observation group were lower than those in the control group(P＜0.05). After treatment，levels of PAF， TXB2 and IL- 8 in the two groups were lower than those before treatment(P＜0.05)， and the three levels in the observation group were lower than those in the control group(P＜0.05). After treatment， whole blood viscosity， plasma viscosity，hematocrit and fibrinogen levels in the two groups were decreased when compared with those before treatment， and the above four levels in the observation group were lower than those in the control group(P＜0.05). Conclusion：Tianma Huoxue tang combined with flunarizine hydrochloride capsules has a relatively good clinical effect in the treatment of vertigo symptom due to insufficiency of cerebral blood supply. It can relieve vertigo symptom， regulate serological indexes and hemorheological indexes，and improve quality of life.