Abstract： By sorting out the medical records of MA Peizhi's treatment of atrophy syndrome in Menghe Sijia Yiji and analyzing the pathogenesis of the medical records， the academic characteristics of MA Peizhi were analyzed by means of determining the syndrome through herbs. MA believed that the disease location of atrophy syndrome was muscle，bone and flesh， and the pathogenesis was mainly the imbalance of qi， blood， yin and yang. His treatment for atrophy syndrome featured as follows： Frist， to supplement deficiency as main treatment and to harmonize qi and blood； Second， to harmonize nutrient qi and regulate qi and to dispel pathogen to prevent disease； Third， to apply both clearing and supplementing and treat yangming according to different syndromes.