Abstract： Objective： To observe the clinical effect of acupuncture therapy combined with Jieyu Tongqiao tang for schizophrenia. Methods：A total of 102 cases of patients with schizophrenia were randomly divided into the treatment group and the control group，51 cases in each group. The control group was given chloropromazine，and the treatment group was additionally given acupuncture combined with Jieyu Tongqiao tang based on the treatment of the control group. After onemonth treatment，statistical analysis of clinical effect and incidence of adverse reactions in the two groups was carried out. Before and after treatment， scores of Positive and Negative Syndrome Scale(PANSS)， Scale for Assessment of Negative Symptoms(SANS)，Hamilton Depression Scale(HAMD)，and Generic Quality of Life Inventory-74(GQOLI-74) were compared between the two groups. Results： The total effective rate was 96.08% in the treatment group and 78.43% in the control group，the difference being significant(P＜0.05). Before treatment，when compared scores of positive symptoms，negative symptoms，and general pathology of PANSS，as well as the total scores between the two groups，there was no significance being found in the difference(P＞0.05). After treatment， scores of positive symptoms， negative symptoms， and general pathology，as well as the total scores in the two groups were decreased when compared with those before treatment(P＜ 0.05)；scores of negative symptoms and general pathology，as well as the total score in the treatment group were lower than those in the control group(P＜0.05)；there was no significant difference being found in the comparison of scores of positive symptoms between the two groups(P＞0.05). Before treatment， there was no significant difference being found in the comparison of scores of SANS and HAMD between the two groups(P＞0.05). After treatment，scores of SANS and HAMD in the two groups were decreased when compared with those before treatment(P＜0.05)，and the two scores in the treatment group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of scores of GQOLI- 74 between the two groups(P＞0.05). After treatment，scores of GQOLI- 74 in the two groups were increased when compared with those before treatment(P＜0.05)，and the score in the treatment group was higher than that in the control group(P＜0.05). The incidence of adverse reactions was 5.88% in the treatment group and 19.61% in the control group，the difference being significant(P＜0.05). Conclusion：In the treatment of schizophrenia，the therapy of acupuncture combined with Jieyu Tongqiao tang and chloropromazine can enhance clinical effect and quality of life，effectively relieve clinical symptoms and degree of depression，and reduce adverse reactions.