Abstract：Objective：To observe the prevention and control effect and mechanism of Yangyin Qingfei Huoxue method on radiation-induced lung injury after radiotherapy for non-small cell lung cancer(NSCLC) with deficiency of qi and yin. Methods： A total of 100 cases of NSCLC patients with deficiency of qi and yin were selected and divided into the control group and the observation group according to the random number table method，with 50 cases in each group. The control group was treated with conventional radiation，and the observation group was additionally treated with Yangyin Qingfei Huoxue method based on the treatment of the control group. Both groups were treated for 12 weeks. Before and after treatment，symptom scores and inflammatory factors levels in the two groups were compared. The radiation- induced effects， incidences of radiation pneumonitis and radiation- induced pulmonary fibrosis in the two groups were compared. Results： After treatment， the scores of cough， fever， chest pain and dyspnea in the two groups were decreased when compared with those before treatment(P＜0.05)， and the scores of cough， fever， chest pain and dyspnea in the observation group were lower than those in the control group(P＜0.05). The radiation- induced effect in the observation group was 68.00% and 72.00% in the control group，there was no significant difference being found in the comparison in the two groups(P＞0.05). After treatment for 4，8，12 weeks，the levels of tumor necrosis factor-α(TNF-α)，transforming growth factor-β(TGF-β) and interleukin-6 (IL- 6) in the observation group were lower than those in the control group at the same period(P＜0.05). The incidences of radiation pneumonitis and radiation- induced pulmonary fibrosis were 34.00% and 14.00% in the observation group， lower than those of 54.00% and 32.00% in the control group(P＜0.05). Conclusion：Yangyin Qingfei Huoxue method can effectively improve the clinical symptoms of NSCLC patients with deficiency of qi and yin， reduce the incidence of radiation- induced lung injury after radiotherapy，whose mechanism may be related to the reduction of levels of inflammatory factors.