Abstract：Objective：To observe the clinical effect of fumigation and washing with Shujin Yangxue tang combined with mirror therapy for shoulder-hand syndrome after cerebral infarction. Methods：A total of 116 cases of patients with shoulderhand syndrome after cerebral infarction were randomly divided into the observation group and the control group ， with 58 cases in each group. The control group was given mirror therapy，and the observation group was treated with fumigation and washing with Shujin Yangxue tang combined with mirror therapy. Both groups were treated for four weeks. Before treatment and after four- week treatment，the pain degrees of shoulder joint in the injured side[Visual Analogue Scale(VAS) scores]， swelling degrees and motor dysfunction degrees[Fugl- Meyer Assessment for upper extremity(FMA- UE)] were evaluated. The levels of substance P(SP)，5-hydroxytryptamine(5-HT) and prostaglandin E2(PGE2) were detected. The clinical effects and the incidences of adverse reactions in the two groups were compared. Results：After four-week treatment，the total effective rate of clinical effect was 93.10% in the observation group and 77.59% in the control group， the difference being significant(P＜0.05). The VAS scores and the swelling values in the two groups were decreased when compared with those before treatment， and FMA- UE scores were increased， differences being significant(P＜0.05)； VAS score and swelling value in the observation group were lower than those in the control group， and FMA- UE score was higher， differences being significant(P＜0.05). After treatment，the levels of SP，5- HT and PGE2 in serum in the two groups were decreased when compared with those before treatment， differences being significant(P＜0.05)； the levels of SP， 5-HT and PGE2 in serum in the observation group were lower than those in the control group differences being significant(P＜0.05). The incidence of adverse reactions was 6.90% in the observation group and 3.45% in the control group， there being no significance in the difference(P＞0.05). Conclusion： The application of fumigation and washing with Shujin Yangxue tang combined with mirror therapy for shoulder- hand syndrome after cerebral infarction can effectively relieve symptoms and pain，and improve clinical effects，with good safety.