Abstract：Objective：To observe the clinical effect of Xianling Gubao capsules assisted surgery on non-traumatic femoral head necrosis. Methods：A total of 92 patients with non-traumatic femoral head necrosis were selected and divided into the control group and the observation group according to random number table method，with 46 cases in each group. The control group was given bone grafting through fenestration at head and neck fenestration for treatment and after surgery treated with routine medicine. The observation group was orally treated with Xianling Gubao capsules on the second day after surgery based on the treatment of the control group，and the medication lasted for one year. The Harris scores，clinical effects and incidence of adverse reactions were compared between the two groups. Results：One year after surgery，the scores of pain degree，joint deformity，range of joint motion，joint function and the total scores in the two groups were increased when compared with those before surgery(P＜0.05)，and the above scores in the observation group were higher than those in the control group(P＜0.05). One year after surgery，the clinical effect in the observation group was better than that in the control group，the difference being significant(P＜0.05). The incidence of adverse reactions was 6.52% in the observation group and 10.87% in the control group，there being no significant difference between the two groups(P＞0.05). Conclusion：Xianling Gubao capsules assisted surgery for non- traumatic femoral head necrosis can improve the speed of postoperative rehabilitation with great safety.