Abstract： Objective： To observe the clinical effect of Tongxuan Lifei granules combined with budesonide formoterol inhalation on chronic obstructive pulmonary disease(COPD) in acute attack stage. Methods：A total of 84 patients with COPD in acute attack stage were selected and divided into the control group and the observation group according to the random number table method，with 42 cases in each group. The control group was treated with budesonide formoterol inhalation， and the observation group was additionally treated with Tongxuan Lifei granules based on the treatment of the control group. Both groups were treated for seven days. The clinical effects and incidence of adverse reactions were compared between the two groups；before and after treatment，the forced vital capacity(FVC)，forced expiratory volume in one second(FEV1)，FEV1/FVC， numbers of acute attacks，scores of Saint George Respiratory questionnaire(SGQR)，Six-Minute Walk Distance(6MWD) and syndrome scores were compared between the two groups. Results：The total effective rate was 95.24% in the observation group，higher than that of 78.57% in the control group(P＜0.05). After treatment，the FVC，FEV1 and FEV1/FVC in the two groups were increased when compared with those before treatment(P＜0.05)， and the above indexes in the observation group were higher than those in the control group(P＜0.05). After treatment， the SGQR scores in both groups were decreased when compared with those before treatment(P＜0.05)，and the 6MWD was increased(P＜0.05)；the SGQR score in the observation group was lower than that in the control group(P＜0.05)， and the 6MWD was longer(P＜0.05). After treatment，the scores of cough，expectoration and heavy breath in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above scores in the observation group were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 11.90% in the observation group，and 9.52% in the control group，there being no significance in the difference(P＞0.05). Conclusion： The therapy of Tongxuan Lifei granules combined with budesonide formoterol inhalation has a good curative effect on COPD in acute attack stage，which can improve the clinical symptoms，lung function，exercise endurance and quality of life of patients，with high safety.