Abstract：Objective：To observe the clinical effect and safety of Jieyu Yizhi tang for Alzheimer disease of liver depression and spleen deficiency type. Methods：A total of 100 cases of patients with Alzheimer disease were randomly divided into two groups，with 50 cases in each group. The control group was given the oral administration of donepezil hydrochloride，and the observation group was given the oral administration of Jieyu Yizhi tang. After treatment，Chinese medicine symptom scores， MMSE scale scores， Activities of Daily Living(ADL) scores， clinical effects and incidences of adverse reactions in the two groups were compared and analyzed to evaluate the effect and safety of Jieyu Yizhi tang for Alzheimer disease. Results：After treatment， the scores of ADL， MMSE and Chinese medicine symptom scale in the two groups were improved when compared with those before treatment，differences being significant(P＜0.05). The improvement of the scores of ADL and Chinese medicine symptom scale in the observation group was better than that in the control group(P＜0.05)，the difference being significant；there was no significant difference being found in the comparison of MMSE scores between the two groups (P＞0.05). The total effective rate of ADL and Chinese medicine symptom scores in the observation group were higher than those in the control group， differences being significant(P＜0.05)； there was no significant difference being found in the comparison of the total effective rates of MMSE scores between the two groups(P＞0.05)；the incidence of adverse reactions in the control group was higher than that in the observation group， the difference being significant(P＜0.05). Conclusion： Jieyu Yizhi tang can improve the activities of daily living and Chinese medicine symptoms of patients with Alzheimer disease of liver depression and spleen deficiency type. Its clinical effect is superior to donepezil hydrochloride tablets， with the advantages of less toxicity and higher safety.