Abstract： Objective： To observe the effect of Bushen Huoxue prescription combined with carbidopa and levodopa sustained- release tablets on levels of adiponectin， tumor necrosis factor- α(TNF- α) and Interleukin(IL- 6) in serum and cognitive function of patients with Parkinson disease(PD). Methods： A total of 72 cases of PD patients were selected and divided into the treatment group 1 and the treatment group 2 according to the random number table method，with 36 cases in each group； 50 people who had physical examinations in the same period and received healthy results were selected and included in the control group. The treatment group 1 was treated with carbidopa and levodopa sustained-release tablets，and the treatment group 2 was treated with carbidopa and levodopa sustained- release tablets and Bushen Huoxue prescription. Changes in levels of adiponectin，TNF- α and IL- 6 in serum in the two groups before and after treatment were compared. The cognitive function was evaluated by Mini- Mental State Examination(MMSE). Results： Before treatment， levels of adiponectin in the treatment group 1 and the treatment group 2 were decreased when compared with those in the control group， and levels of TNF- α and IL- 6 were increased， differences being significant(P＜0.05)； there was no significant difference being found in the comparison of levels of adiponectin，TNF-α and IL-6 between the treatment group 1 and the treatment group 2(P＞0.05). After treatment，levels of adiponectin in the treatment group 1 and the treatment group 2 were increased when compared with those before treatment，and levels of TNF-α and IL-6 were decreased，the difference being significant(P＜0.05)；level of adiponectin in the treatment group 2 was higher than that in the treatment group 1，and levels of TNF- α and IL- 6 were lower than those in the treatment group 1， differences being significant(P＜0.05). Before treatment，when compared scores of immediate memory，language，orientation，attention and calculation，and delayed recall as well as the total scores in MMSE scale between the treatment group 1 and the treatment group 2，there was no significance being found in the difference(P＞0.05). After treatment，each score and the total score in MMSE scale in the two groups were increased when compared with those before treatment(P＜0.05)，and the increase of each score and the total score in the treatment group 2 was more significant than that in the treatment group 1(P＜0.05). Conclusion：Bushen Huoxue prescription combined with carbidopa and levodopa sustained- release tablets can effectively enhance serum adiponectin of PD patients，reduce inflammation level and improve cognitive function. It has better curative effect than the simple application of carbidopa and levodopa sustained-release tablets.