Abstract： Objective： To observe the clinical effect of Wenxin granules combined with routine western medicine for angina pectoris of coronary heart disease. Methods：A total of 112 cases of patients with angina pectoris of coronary heart disease were selected as the study subjects and divided into the treatment group and the control group according to the random number table method group，with 58 and 54 cases in each group respectively. The control group was treated with enteric coated aspirin tablets，isosorbide nitrate tablets and other routine western medicine，and the treatment group was additionally treated with Wenxin granules based on the treatment of the control group. The clinical effects in the two groups were observed. The number and duration of angina pectoris attacks， and levels of hemorheological indexes [erythrocyte sedimentation rate(ESR)， fibrinogen(Fib)， whole blood viscosity and plasma viscosity] before and after treatment were observed. Results： The total clinical effect was 93.10% in the treatment group， higher than that of 79.63% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the number and duration of angina pectoris attacks between the two groups(P＞0.05). After treatment， number and duration of angina pectoris attacks in the two groups were significantly decreased when compared with those before treatment(P＜0.05)；the number in the treatment group was smaller than that in the control group，and the duration was shorter(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of ESR， Fib， whole blood viscosity and plasma viscosity between the two groups(P＞0.05). After treatment， levels of ESR， Fib， whole blood viscosity and plasma viscosity in the two groups were significantly decreased when compared with those before treatment(P＜0.05)， and the above indexes in the treatment group were lower than those in the control group(P＜0.05). Conclusion： Wenxin granules combined with routine western medicine has a significant clinical effect in the treatment of angina pectoris of coronary heart disease， which can reduce the frequency and duration of angina pectoris attacks， and improve hemorheological indexes.