Abstract： Objective： To observe the clinical effect of Longdan Xiegan tang combined with eszopiclone tablets for insomnia with liver constraint transforming into fire syndrome. Methods：A total of 70 cases of patients with insomnia with liver constraint transforming into fire syndrome were divided into the control group and the observation group according to the random number table method，with 35 cases in each group. The control group was treated with eszopiclone tablets，and the observation group was additionally treated with Longdan Xiegan tang based on the treatment of the control group. Both groups were treated for four weeks. The sleep quality before and after treatment as well as，the clinical effects and the incidences of adverse reactions in the two groups were compared. Results：The total effective rate was 94.29% in the observation group， higher than that of 77.14% in the control group(P＜0.05). After treatment，the scores of Pittsburgh Sleep Quality Index(PSQI) and Insomnia Severity Index(ISI) in the two groups were decreased when compared with those before treatment(P＜0.05)， and the scores of PSQI and ISI in the observation group were lower than those in the control group(P＜0.05). After treatment， sleep latency(SL) in the two groups were shortened when compared with those before treatment(P＜0.05)，the total sleep time(TST) was prolonged(P＜0.05)，and AT was decreased(P＜0.05)；SL in the observation group was shorter than that in the control group(P＜0.05)， TST was longer(P＜0.05)， and AT was less(P＜0.05). The incidence of adverse reactions was 14.29% in the observation group，and 8.57% in the control group，there being no significant difference(P＞0.05). Conclusion： Longdan Xiegan tang combined with eszopiclone tablets for insomnia with liver constraint transforming into fire syndrome can improve curative effect and effectively improve sleep quality with good safety.