Abstract：Objective：To observe the clinical effect of the therapy of modified Gexia Zhuyu tang combined with western medicine for hepatitis B cirrhosis. Methods：A total of 120 patients with hepatitis B cirrhosis were selected and divided into the observation group and the control group according to the random number table method，with 60 cases in each group. The control group was treated with western medicine， and the observation group was additionally treated with modified Gexia Zhuyu tang based on the treatment of the control group. Both groups were treated for 24 weeks. The clinical effects and adverse reactions in the two groups were compared ； before and after treatment， the Chinese medicine syndrome scores and levels of hemodynamic indexes[diameter of portal vein(Dpv)，diameter of splenic vein(Dsv)，mean blood velocity of splenic vein(Ssv) and blood flow volume of portal vein(Qpv)]， liver fibrosis indexes[serum hyaluronic acid(HA)， procollagen Ⅲ(PCⅢ)，typeⅣcollagen(Ⅳ-C) and laminin(LN)]，liver function indexes[alanine aminotransferase(ALT)，aspartate aminotransferase(AST)， albumin(Alb) and total bilirubin(TBil)]， serum transforming growth factor- β1(TGF- β1) and tissue inhibitor of metalloproteinase- 1(TIMP- 1) were compared between the two groups. Results： The total effective rate was 88.33% in the observation group， higher than that of 68.33% in the control group(P＜0.05). After treatment， the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.05)， and the Chinese medicine syndrome score in the observation group was lower than that in the control group(P＜0.05). After treatment， the Dpv， Dsv and Qpv in the two groups were decreased when compared with those before treatment(P＜ 0.05)，and the Ssv was increased(P＜0.05)；the Dpv，Dsv and Qpv in the observation group were lower than those in the control group(P＜0.05)，and the Ssv was higher(P＜0.05). After treatment，the levels of HA，LN，PCⅢ，Ⅳ-C，ALT，AST， TBil，TGF- β1 and TIMP- 1 in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above levels in the observation group were lower than those in the control group(P＜0.05)； the Alb levels in the two groups were increased when compared with those before treatment(P＜0.05)，and the Alb level in the observation group was higher than that in the control group(P＜0.05). During the treatment，no serious medicine-related adverse reactions occurred in both groups. Conclusion： The therapy of modified Gexia Zhuyu tang combined with western medicine for hepatitis B cirrhosis can effectively improve the clinical symptoms，hemodynamics and liver fibrosis of patients，promote the recovery of the liver function，and reduce the levels of serum TGF-β1 and TIMP-1，with high safety.