Abstract： Objective： To summarize the administration rule of Prof. WANG Bangcai in treating depression syndrome. Methods： A total of 200 prescriptions for the first consultation of 200 patients with depression syndrome from January 2020 to March 2021 in the outpatient department of Prof. WANG of Ningbo Hospital of Traditional Chinese Medicine were collected. The Traditional Chinese Medicine Inheritance Auxiliary Platform System(V3.0) was used for data mining. Through statistical analysis， prescription analysis and other data mining methods of the software， the administration rule of Prof. WANG Bangcai in treating depression syndrome was analyzed and studied. Results： Totally 200 prescriptions were included， 128 Chinese herbs were included. There were 38 high-frequency herbs，mainly including Poria，Fructus Tritici， Radix Bupleuri， Rhizoma Pinelliae， Radix Paeoniae Alba， Fructus Gardeniae， Pericarpium Citri Reticulatae， Radix Curcumae， Rhizoma Cyperi and Radix Polygalae， etc. The effect of the herbs mainly included clearing heat， tonifying deficiency， regulating qi， releasing the exterior， dissolving phlegm， promoting blood and removing stasis. The flavors of herbs were mainly bitter，acrid and sweet；the natures of herbs were mainly cold，warm and neutral；the lung channel and spleen channel dominated in terms of channel entry. Based on the analysis of association rule， 26 high- frequency herbal combinations and 24 association rules were mined. Five core combinations were obtained by cluster analysis. Conclusion：In the treatment of depression syndrome，Prof. WANG advocates to regulate the body and mind simultaneously and promote qi movement. The general medication mainly includes bitter，acrid and sweet herbs，which can reflect the treatment methods of using both cold and warm herbs，regulating the qi and blood simultaneously，combining fierce herbs with soften herbs， and harmonizing the core.