Abstract：Based on ancient literature on the application of “turbidity” in andrology，this paper explores the mechanism of "turbidity" in male infertility， and explores the relationship between the pathogenic factors of sperm DNA damage and "turbidity pathogen". It is believed that turbidity pathogen is not only a pathological product，but also a pathogenic factor，a transitional stage to sperm nucleus damage， and a link between high- risk pathogenic factors and sperm DNA damage. Resolving turbidity is the key to avoiding sperm nucleus damage，and a new idea of treating male infertility with sperm DNA damage.