Abstract：Objective：To observe the effect of the therapy of Chinese medicine lavage and negative pressure technique combined with the external application of Shengji Yuhong ointment on the level of inflammatory factors in patients with diabetic foot of damp-heat type. Methods：A total of 120 patients with diabetic foot of damp-heat type were selected and divided into the control group and the study group according to the random number table method， with 60 cases in each group. The control group was treated with basic treatment and Shengji Yuhong ointment， and the study group was additionally treated with Chinese medicine lavage and negative pressure technique based on the treatment of the control group. Both groups were treated for one month continuously. Before and after treatment， the changes of levels of inflammatory factors， including interleukin- 13(IL- 13)， tumor necrosis factor- α(TNF- α) and interleukin- 6(IL- 6)， area of wound， morphology of wound and symptoms were compared between the two groups. After treatment， the degree of wound healing and clinical effects were compared between the two groups. Results：After treatment，the levels of IL-13， TNF-α and IL-6 in the two groups were decreased when compared with those before treatment，and the above three levels in the study group were lower than those in the control group，differences being significant(P＜0.05). After treatment，the area of wound in both groups was decreased when compared with that before treatment(P＜0.05)，and the area of wound in the study group was smaller than that in the control group(P＜0.05)； the degree of wound healing in the study group was higher than that in the control group， the difference being significant(P＜0.05). After treatment， the scores of color and morphology of granulation， smell， redness and swelling around the wound， secretion and pain in the two groups were decreased when compared with those before treatment and the above five scores in the study group were lower than those in the control group，differences being significant(P＜0.05). After treatment，the total effective rate was 95.00% in the study group，and was 81.67% in the control group，the difference being significant(P＜0.05). Conclusion：The therapy of Chinese medicine lavage and negative pressure technique combined with external application of Shengji Yuhong ointment for diabetic foot of damp-heat type can inhibit the inflammatory responses，promote the wound healing，enhance the clinical effect.