Abstract：Objective：To observe the clinical effect of meridian sinew row needling combined with rehabilitation training for post- stroke shoulder- hand syndrome stage I and its effect on upper limb motor function and inflammatory factors. Methods：A total of 90 cases of patients at stage I of post-stroke shoulder-hand syndrome were selected and divided into the observation group and the control group according to the random number table method，with 45 cases in each group. The control group was treated with routine acupuncture and rehabilitation training，and the observation group was treated with meridian sinew row needling and rehabilitation training. Clinical effects，upper limb motor function and levels of inflammatory factors were compared between the two groups. Results： The total clinical effective rate was 95.56% in the observation group，higher than that of 80.00% in the control group(P＜0.05). Before treatment，when compared scores of Fugl-Meyer Assessment for upper limb function， Visual Analogue Scale(VAS) for pain， edema degree and Barthel index， as well as inflammatory factors [interleukin- 6(IL- 6)， tumor necrosis factor- α(TNF- α)， C- reactive protein(CRP)] between the two groups，there was no significance in the difference(P＞0.05). After treatment，scores of Fugl-Meyer and Barthel index in the two groups were higher than those before treatment，and VAS scores，edema degree，and levels of IL-6，TNF-α and CRP were lower(P＜0.05). After treatment， scores of Fugl- Meyer and Barthel index in the observation group were higher than those in the control group， and VAS scores， edema degree， and levels of IL- 6， TNF- α and CRP were lower(P＜0.05). Conclusion：The therapy of meridian sinew row needling combined with rehabilitation training has a significant curative effect in the treatment of patients at stage I of post-stroke shoulder-hand syndrome. It can improve upper limb motor function and self-care ability，relieve joint pain，edema and body inflammatory response，and conduce to the recovery from the disease.