Abstract：Objective：To observe the analgesic effect of acupuncture combined with nerve block for patients with knee arthroplasty and its effect on early function recovery in joints. Methods： A total of 90 cases of patients undergoing knee arthroplasty were divided into the observation group and the control group according to the random number table method， with 45 cases in each group. The control group was simply treated with nerve block， and the observation group was additionally treated with acupuncture based on the treatment of the control group. The recovery of early function recovery and the incidence of adverse reactions in the two groups were compared. After operation immediately，and 48 hours and 7 days after operation respectively，the scores of Visual Analogue Scale(VAS) in pain and the levels of serological indicators in the two groups were compared. Results：At 48 hours and 7 days after operation respectively，VAS scores and levels of tumor necrosis factor- α(TNF- α) and interleukin- 6(IL- 6) in the two groups were decreased when compared with those after operation immediately(P＜0.05)，and the VAS score and levels of TNF-α and IL-6 in the observation group were lower than those in the control group(P＜0.05). After operation，range of motion(ROM) in the two groups was increased when compared with that before treatment(P＜0.05)，ROM in the observation group was bigger than that in the control group(P＜0.05)，and Hospital for speical surgery(HSS) score was higher(P＜0.05). There was no significant difference being found in the comparison of incidences of impaired wound healing and dizziness between the two groups(P＜0.05). The incidence of adverse reactions of nausea and vomiting in the observation group was lower than that in the control group(P＜0.05). Conclusion：Acupuncture combined with nerve block has a significant analgesic effect in the treatment of knee arthroplasty， which can improve the effective rate of early function recovery and reduce the incidence of adverse reactions.