Abstract：Objective：To observe the clinical effect of modified Chaihu Liuwei tang combined with salmeterol fluticasone powder inhalation for cough variant asthma(CVA) in children. Methods：A total of 90 cases of CVA children were divided into the control group and the observation group according to the random number table method，with 45 cases in each group. The control group was treated with salmeterol fluticasone powder inhalation，and the observation group was additionally treated with modified Chaihu Liuwei tang based on the treatment of the control group. Symptom scores， the lung function， and levels of serum indexes before and after treatment as well as clinical effects and the remission time of symptoms were compared between the two groups. Results：The total effective rate was 93.33% in the observation group，higher than that of 77.78% in the control group(P＜0.05). When compared with those in the same group before treatment，the daytime and nighttime symptom scores， eosinophil(EOS) counts， and immunoglobulin E(IGE) levels in peripheral blood after treatment were decreased in the two groups(P＜0.05)，and levels of peak respiratory flow rate(PEFR)，forced expiratory volume in the first second(FEV1)，and forced expiratory volume in the first second/forced vital capacity(FEV1/FVC) were increased(P＜0.05). After treatment，the daytime and nighttime symptom scores as well as levels of EOS and IgE in the observation group were lower than those in the control group(P＜0.05)， and levels of PEFR， FEV1， and FEV1/FVC were higher(P＜0.05). The remission time and disappearance time of cough in the observation group were shorter than those in the control group(P＜ 0.05). Conclusion：The therapy of modified Chaihu Liuwei tang combined with salmeterol fluticasone powder inhalation has a defined curative effect in the treatment of CVA，which can quickly control clinical symptoms and improve the lung function.