Abstract：Objective：To observe the effect of Shenmai injection on inflammatory factors and prognosis of patients with septic shock. Methods：A total of 94 cases of patients with septic shock were randomly divided into the control group and the observation group，with 47 cases in each group. The control group was treated with standardized western medicine，and the observation group was additionally treated with intravenous infusion with Shenmai injection based on the treatment of the control group. Before and after treatment，scores of the Acute Physiology and Chronic Health Evaluation-Ⅱ(APACHE-Ⅱ)， mean arterial pressure(MAP)，heart rate(HR)，tumor necrosis factor-α(TNF-α)，and interleukin-1β(IL-1β) were compared between the two groups. Clinical effects and prognosis were compared between the two groups. Results：The total effective rate was 89.36% in the observation group，higher than that of 72.34% in the control group(P＜0.05). After treatment，MAP in the two groups were increased when compared with those before treatment(P＜0.05)， and HR， APACHE- Ⅱ scores and levels of TNF- α，and IL- 1β were decreased(P＜0.05). After treatment，when compared with those in the control group， MAP in the observation group was higher(P＜0.05)， and HR， APACHE- Ⅱ scores and levels of TNF- α， and IL- 1β were lower(P＜0.05). The mortality rate after 28-day hospitalization in the observation group was lower than that in the control group (P＜0.05)， and the mechanical ventilation time and intensive care unit(ICU) treatment time in the observation group were shorter(P＜0.05). No obvious adverse response occurred in the two groups. Conclusion： Shenmai injection combined with routine treatment for patients with septic shock can improve their heart function and kidney function，relieve the state of body inflammation，and improve clinical effective rate with a good prognosis.