Abstract：Objective：To observe the clinical effect of compound Houtou granules combined with western medicine for senile gastric ulcer and its effect on serological indexes. Methods： A total of 92 cases of senile patients with gastric ulcer were selected and divided into the treatment group and the control group according to the random number table method， with 46 cases in each group. The control group was treated with routine western medicine， and the treatment group was additionally treated with compound Houtou granules based on the treatment of the control group. The clinical effects in the two groups were compared； the changes of Chinese medicine syndrome scores and serological indexes including malonaldehyde(MDA)，superoxide dismutase(SOD) and nitric oxide(NO) before and after treatment in the two groups were compared； the incidences of adverse reactions in the two groups were observed. Results： After treatment， the total effective rate was 80.43% in the control group and 95.65% in the treatment group，the difference being significant(P＜0.05). After treatment， Chinese medicine syndrome scores of abdominal pain， loss of appetite， acid reflux and abdominal distention in the two groups were decreased when compared with those before treatment， and the above four Chinese medicine syndrome scores in the treatment group were lower than those in the control group，differences being significant (P＜0.05). After treatment，MDA levels in the two groups were decreased when compared with those before treatment，and the levels of SOD and NO were increased， differences being significant(P＜0.05)； MDA level in the treatment group was lower than that in the control group，and the levels of SOD and NO were higher，differences being significant(P＜0.05). In the control group， there were two cases of nausea and two cases of insomnia， and the incidence of adverse reactions was 8.70%；in the treatment group，there were two cases of diarrhea and three cases of vertigo，and the incidence of adverse reactions was 10.87% . There was no significant difference being found in the comparison of the incidences of adverse reactions between the two groups(χ2=0.123，P=0.726). Conclusion：The application of compound Houtou granules combined with western medicine for senile patients with gastric ulcer can achieve a better clinical effect，alleviate clinical symptoms， improve gastrointestinal movement and promote rehabilitation.