Abstract：Objective：To observe the clinical effect of the therapy of Shugan Wendan tang combined with conventional western medicine on metabolic syndrome(MS). Methods： A total of 94 MS patients were selected and divided into the experiment group and the control group by random number table method，with 47 cases in each group. The control group was treated with conventional western medicine，and the experiment group was treated with Shugan Wendan tang based on the treatment of the control group. The treatment course of both groups was 12 weeks. The serum levels of fasting blood glucose(FBG)，fasting insulin(FIN)，homeostasis model assessment-insulin resistance(HOMA-IR)，hemoglobin A1c(HbA1c)， hypersensitive C-reactive protein(hs-CRP)，tumor necrosis factor - α(TNF- α)，interleukin-1(IL-1) and interleukin-6(IL-6) in both groups before and after treatment were compared. The clinical effects in the two groups were observed. Results： After treatment，the levels of FIN，FBG，HbA1c and HOMA-IR in both groups were decreased when compared with those before treatment(P＜0.05)；after treatment，the above levels in the experiment group were lower than those in the control group，differences being significant(P＜0.05). After treatment，the levels of TNF-α，hs-CRP，IL-1 and IL-6 in both groups were decreased when compared with those before treatment(P＜0.05)；after treatment，the above levels in the experiment group were lower than those in the control group，differences being significant(P＜0.05). The total effective rate was 87.23% in the experiment group， and 59.57% in the control group， the difference being significant(P＜0.05). Conclusion： The therapy of Shugan Wendan tang combined with conventional western medicine can improve glucose metabolism and clinical symptoms of MS patients，alleviate the inflammatory responses and enhance insulin resistance，with great safety.