疏肝温胆汤联合常规西药治疗代谢综合征临床研究
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R589

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Clinical Study on Shugan Wendan Tang Combined with Conventional Western Medicine for Metabolic Syndrome
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    摘要:

    目的:观察疏肝温胆汤联合常规西药治疗代谢综合征(MS) 的临床疗效。方法:选取94 例MS 患者,按随机数字表法分为试验组和对照组各47 例。对照组给予常规西药治疗,试验组在对照组的基础上加用疏肝温胆汤治疗,2 组疗程均为12 周。比较2 组治疗前后血清空腹血糖(FBG)、空腹胰岛素(FIN)、胰岛素抵抗指数(HOMA-IR)、糖化血红蛋白(HbA1c)、超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、白细胞介素6(IL-6) 的变化,观察2 组临床疗效。结果:治疗后,2 组FIN、FBG、HbA1c、HOMA-IR 水平均较治疗前下降(P<0.05);治疗后,试验组FIN、FBG、HOMA-IR、HbA1c 水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组TNF-α、hs-CRP、IL-1 及IL-6 均较治疗前下降(P<0.05);治疗后,试验组TNF-α、hs-CRP、IL-1 及IL-6 水平均低于对照组,差异均有统计学意义(P<0.05)。试验组临床疗效总有效率为87.23%,对照组总有效率为59.57%,2 组比较,差异有统计学意义(P<0.05)。结论:疏肝温胆汤联合常规西药治疗MS,可改善MS 患者的糖代谢及临床症状,减轻机体的炎症反应,改善胰岛素抵抗,用药安全性较高。

    Abstract:

    Abstract:Objective:To observe the clinical effect of the therapy of Shugan Wendan tang combined with conventional western medicine on metabolic syndrome(MS). Methods: A total of 94 MS patients were selected and divided into the experiment group and the control group by random number table method,with 47 cases in each group. The control group was treated with conventional western medicine,and the experiment group was treated with Shugan Wendan tang based on the treatment of the control group. The treatment course of both groups was 12 weeks. The serum levels of fasting blood glucose(FBG),fasting insulin(FIN),homeostasis model assessment-insulin resistance(HOMA-IR),hemoglobin A1c(HbA1c), hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor - α(TNF- α),interleukin-1(IL-1) and interleukin-6(IL-6) in both groups before and after treatment were compared. The clinical effects in the two groups were observed. Results: After treatment,the levels of FIN,FBG,HbA1c and HOMA-IR in both groups were decreased when compared with those before treatment(P<0.05);after treatment,the above levels in the experiment group were lower than those in the control group,differences being significant(P<0.05). After treatment,the levels of TNF-α,hs-CRP,IL-1 and IL-6 in both groups were decreased when compared with those before treatment(P<0.05);after treatment,the above levels in the experiment group were lower than those in the control group,differences being significant(P<0.05). The total effective rate was 87.23% in the experiment group, and 59.57% in the control group, the difference being significant(P<0.05). Conclusion: The therapy of Shugan Wendan tang combined with conventional western medicine can improve glucose metabolism and clinical symptoms of MS patients,alleviate the inflammatory responses and enhance insulin resistance,with great safety.

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郭永宁,刘淑玲,蔡海荣,赵帅,陈伯钧.疏肝温胆汤联合常规西药治疗代谢综合征临床研究[J].新中医,2022,54(7):84-88

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  • 在线发布日期: 2022-04-12
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