Abstract： Objective： To observe the clinical effect of modified Ziyin Xifeng prescription for senile ischemic stroke. Methods：A total of 64 cases of senile patients with ischemic stroke were selected and divided into the observation group and the control group according to the random number table method，with 32 cases in each group. The control group was given routine symptomatic treatment of western medicine，and the observation group was additionally treated with modified Ziyin Xifeng prescription based on the treatment of the control group. Before and after treatment， Chinese medicine syndrome scores， National Institutes of Health Stroke Scale(NIHSS) scores as well as the levels of endothelin- 1(ET- 1) and central nervous system specific protein(S100- β) in serum in the two groups were detected. The clinical effects were evaluated. Results：The total effective rate was 90.63% in the observation group，higher than that of 65.62% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of Chinese medicine syndrome scores and NIHSS scores between the two groups(P＞0.05). After treatment，Chinese medicine syndrome scores and NIHSS scores in the two groups were decreased when compared with those before treatment，and Chinese medicine syndrome score and NIHSS score in the observation group were lower than those in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of ET-1 and S100-β in serum between the two groups(P＞0.05). After treatment，the levels of ET-1 and S100-β in serum in the two groups were decreased when compared with those before treatment，and the levels of ET-1 and S100-β in serum in the observation group were lower than those in the control group， the difference being significant(P＜0.05). Conclusion： Modified Ziyin Xifeng prescription has a good curative effect in treating yin deficiency with stirring wind syndrome in senile ischemic stroke，which can relieve clinical symptoms，improve neurologic impairment symptoms，and regulate vascular endothelial contraction function and levels of central nervous system specific protein.