Abstract：Objective：To observe the effect of Yiqi Fumai injection on the treatment of angina pectoris of coronary heart disease and its effects on the levels of serum cathepsin S ， matrix metalloproteinase- 9(MMP- 9) and hypersensitive C- reactive protein(hs- CRP). Methods： A total of 98 patients with angina pectoris of coronary heart disease and were randomly divided into the observation group and the control group，with 49 cases in each group. The control group was given conventional treatment，and the observation group was additionally given Yiqi Fumai injection based on the treatment of the control group. The effects on the symptom of angina pectoris and electrocardiogram were observed， and the attack frequency，duration and the levels of serum cathepsin S，MMP-9 and hs-CRP in the two groups were compared before and after treatment. Results： The total effective rate of angina pectoris was 91.84% in observation group， higher than that of 75.51% in the control group(P＜0.05). The total effective rate of electrocardiogram in the observation group was 81.63% ， higher than that of 63.27% in the control group(P＜0.05). After treatment， the attack frequency and duration of angina pectoris in both groups were decreased when compared with those before treatment(P ＜ 0.05) ， and the levels of serum Cathepsin S ， MMP- 9 and hs- CRP were decreased(P＜0.05). Compared with that in the control group respectively，the attack frequency and duration of angina pectoris in the observation group were less and shorter(P＜0.05)，and the levels of serum cathepsin S，MMP-9 and hs-CRP were lower(P＜0.05). Conclusion：Yiqi Fumai injection has a significant therapeutic effect on the treatment of angina pectoris of coronary heart disease，which can effectively improve their symptom of angina pectoris and electrocardiogram，and reduce the attack frequency and duration，with great safety.