Abstract： Objective： To investigate the inhibitory effect of luteolin on psoriasis. Methods： Thirty Balb/c mice were selected and induced into psoriasis like mouse model by imiquimod cream. The skin lesions were analyzed by HE staining， enzyme- linked immunosorbent assay， immunohistochemistry and real- time fluorescence quantitative polymerase chain reaction to analyze the inhibitory mechanism of luteolin on psoriasis. Results： Luteolin could improve the symptoms of psoriasis， such as redness， swelling and scaling， and reduce the rate of skin water loss.Luteolin could also reduce the epidermal thickness，but the intervention effect was not obvious at the concentration of 2 mg/mL and 10 mg/mL，and the epidermal thickness at the concentration of 50 mg/mL was lower than that in the model group(P＜0.05).The number of CD8+ T cells in luteolin 10 mg/mL and 50 mg/mL groups was lower than that in model group(P＜0.05). After luteolin intervention，the expression of COX-2 and IL-1β decreased significantly compared with the model group(P＜0.05). The expression of IL-6 in luteolin 10 mg/mL and 50 mg/mL groups was significantly lower than that in model group(P＜0.05). The expression of IFN-γ was significantly lower than that in the model group(P＜0.05).At luteolin 50 mg/mL， the IFN- α/β mRNA synthesis was significantly lower than that in the model group(P＜0.05)，and the expression of IL-17 decreased significantly after luteolin 2 mg/mL and 50 mg/mL intervention，but there was no difference(P＞0.05). Conclusion：Luteolin can reduce the expression of inflammatory factors such as IL- 1β，IL- 6 and COX- 2，can effectively inhibit the production of psoriasis scale and skin redness.