Abstract： This paper introduces the clinical experience of Professor ZHANG Yonghua treating sleep disorders with emotional syndrome differentiation system. Professor ZHANG Yonghua believes that sleep disorders are closely related to emotional factors. For the treatment of sleep disorders，he advocates the application of emotional syndrome differentiation system，which is dominated by emotion differentiation and combined with the differentiation of constitutions and diseases. It is advocated that emotion differentiation should be mainly based on four types，namely vexation and irascibility，excessive thinking and contemplation， sorrow and anxiety， and fear and restlessness； constitution differentiation should be mainly based on three types，namely qi-depression constitution，phlegm-dampness constitution and fire-effulgence constitution； disease differentiation mainly includes insomnia，restless legs syndrome，and obstructive sleep apnea hypopnea syndrome； the pathogenesis should be comprehensively grasped from three aspects， namely emotion differentiation， constitution differentiation and disease differentiation； then medicines are prescribed to achieve the effect of treating body and mind simultaneously.