Abstract：Objective：To discuss the correlation between Chinese medicine syndrome types of colorectal adenomatous polyps and expression of P53 gene and basic fibroblast growth factor(bFGF). Methods：A total of 100 cases of patients with colorectal adenomatous polyps were selected as the study subjects. Patients in the large intestinal dampness-heat syndrome group，the spleen-stomach deficiency syndrome group，the liver depression and qi stagnation syndrome group，the internal stagnation of blood stasis syndrome group，and the internal obstruction of cold syndrome group were enrolled into the study group， with 20 patients per syndrome； all patients underwent electronic colonoscopy to locate polyp and treated with polypectomy. The control group included 20 normal people. The positive expression rates of P53 gene and bFBF were determined by immunohistochemistry and compared between the two groups. Correlation analysis of P53 gene and bFGF expression among different Chinese medicine syndrome types of colorectal adenomatous polyps was performed by SPSS Pearson correlation analysis software. Results：The positive rates of P53 and bFBF in patients with colorectal adenomatous polyps in the study group were higher than those in the control group，the difference being significant(P＜0.05). The positive rates of P53 gene and bFBF in patients with colorectal adenomatous polyps in the large intestinal dampness-heat syndrome group and the spleen- stomach deficiency syndrome group were higher than those in the liver depression and qi stagnation syndrome group， the internal stagnation of blood stasis syndrome group， and the internal obstruction of cold syndrome group，the difference being significant(P＜0.05). The positive rates of P53 gene and bFBF in the large intestinal dampnessheat syndrome group were higher than those in the spleen- stomach deficiency syndrome group， the difference being significant(P＜0.05). When compared positive rates of P53 gene and bFBF among the liver depression and qi stagnation syndrome group， the internal stagnation of blood stasis syndrome group， and the internal obstruction of cold syndrome group，there was no significance being found in the difference(P＞0.05). Syndrome of large intestinal dampness-heat，and spleen-stomach deficiency in patients with colorectal adenomatous polyps were positively correlated with the positive rates of P53 gene and bFGF，the difference being significant(P＜0.05).No obvious correlation was found between syndrome of liver depression and qi stagnation syndrome，internal stagnation of blood stasis and internal obstruction of cold with positive rates of P53 gene and bFGF(P＞0.05). Conclusion： The expression of P53 gene and bFGF positive rates is relatively higher in patients with colorectal adenomatous polyps，and there are certain correlations and statistical differences in their expression under different Chinese medicine syndrome types.