Abstract：Objective：To investigate the prognosis of breast cancer patients with different Chinese medicine syndromes and its correlation with estrogen receptor(ER)， progesterone receptor(PR) and human epidermal growth factor receptor- 2 (HER- 2). Methods： A total of 100 breast cancer patients were retrospectively studied. According to different Chinese medicine syndromes， they were divided into the liver depression and qi stagnation syndrome group(45 cases)， the liverkidney yin deficiency syndrome group(32 cases)， and the blood stasis syndrome group(23 cases). The TNM staging， histopathological grading and the expression of ER，PR，HER-2，breast cancer suppressor gene(P53) and vascular growth factor(VEGF) were compared between the three groups. Results：There was significant difference in the comparison of TNM staging between the three groups(P＜0.05)；the TNM staging in the blood stasis syndrome group was higher than that in the liver- kidney yin deficiency syndrome group and the liver depression and qi stagnation syndrome group(P＜0.05)；the TNM staging in the liver- kidney yin deficiency syndrome group was higher than that in the liver depression and qi stagnation syndrome group(P＜0.05). The histopathological grading in the three groups was compared，the difference being significant (P＜0.05)； the histopathological grading in the blood stasis syndrome group was higher than that in the liver- kidney yin deficiency syndrome group and the liver depression and qi stagnation syndrome group(P＜0.05)；the histopathological grading in the liver- kidney yin deficiency syndrome group was higher than that in the liver depression and qi stagnation syndrome group(P＜0.05). There was no significant difference in the comparison of the ER and PR expression between the three groups (P＞0.05)，and the positive rates of ER and PR were the highest in the liver depression and qi stagnation syndrome group(P＜ 0.05). There was significant difference in the comparison of the HER- 2 expression between the three groups(P＜0.05)，and the positive rate of HER-2 in the blood stasis syndrome group was significantly higher than that in the liver depression and qi stagnation syndrome group and the liver-kidney yin deficiency syndrome group(P＜0.05). There was no significant difference in the comparison of the expression of P53(P＞0.05)， and the positive rate of P53 was the highest in the blood stasis syndrome group. There was significant difference in the comparison of the VEGF expression between the three groups(P＜ 0.05)， and the positive rate of VEGF in the blood stasis syndrome group was significantly higher than that in the liver depression and qi stagnation syndrome group and the liver- kidney yin deficiency syndrome group(P＜0.05). Conclusion： There are differences in pathological classification and histopathological grading of breast cancer patients with different Chinese medicine syndromes，and their prognosis is closely related to the expression of ER，PR and HER-2 receptors.