Abstract： Objective： To observe the effect of Yiqi Shufeng tang combined with cetirizine hydrochloride tablets for patients with chronic urticaria of blood deficiency and wind- dryness type. Methods： A total of 128 cases of patients with chronic urticaria of blood deficiency and wind- dryness type were divided into two groups according to the random number table method. The control group was treated with cetirizine hydrochloride tablets，and the observation group was treated with Yiqi Shufeng tang combined with cetirizine hydrochloride tablets. Both groups were treated for four weeks. Before and after treatment，the symptom scores of severity including pruritus，number of wheal，maximum diameter of wheal，duration of wheal，appearance of wheal，and attack frequency of wheal，and the scores of Dermatology Life Quality Index(DLQI) in the two groups were evaluated. The levels of CC chemokines including monocyte chemoattractant protein-1(MCP-1)，regulation on activation normal T-cell expressed and secreted(Rantes) and eosinophil chemokine(Eotaxin)，immunoglobulin E(IgE)，and complement C3 and C4 were detected. The clinical effects， incidences of adverse reactions and recurrences in the two groups were counted. Results：After four-week treatment，the total effective rate of clinical effect in the observation group was higher than that in the control group(P＜0.05). The scores of pruritus，number of wheal，maximum diameter of wheal， duration of wheal，appearance of wheal，and attack frequency of wheal in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above six scores of severity of urticaria in the observation group were lower than those in the control group (P＜0.05). The levels of MCP-1，Rantes and Eotaxin in the two groups were decreased when compared with those before treatment (P＜0.05)，and the three levels in the observation group were lower than those in the control group(P＜0.05). The levels of complement C3 and C4 in the two groups were increased when compared with those before treatment(P＜0.05)，and IgE levels were decreased(P＜0.05)；the levels of complement C3 and C4 in the observation group were higher than those in the control group(P＜0.05)，and IgE level was lower(P＜0.05). The DLQI scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the DLQI score in the observation group was lower than that in the control group(P＜0.05). There was no significant difference being found in the comparison of incidences of adverse reactions and recurrences between the two groups(P＞0.05). Conclusion：Yiqi Shufeng tang combined with cetirizine hydrochloride tablets for chronic urticaria can effectively relieve symptoms， regulate immune function， and improve curative effect and quality of life.