Objective：To observe the clinical effect of Yiqi Huoxue Qufeng prescription combined with western medicine for primary immunoglobulin(Ig) A nephropathy. Methods：A total of 86 cases of patients with primary IgA nephropathy were selected and divided into the control group and the observation group according to the random number table method，with 43 cases in each group. The control group was treated with prednisone acetate combined with valsartan，and the observation group was additionally treated with Yiqi Huoxue Qufeng prescription based on the treatment of the control group. Both groups were treated for three months. The clinical effects and the incidences of adverse reactions were compared between the two groups. Before and after treatment， Chinese medicine syndrome scores， kidney function indexes including blood urea nitrogen(BUN)， serum creatinine(SCr) and glomerular filtration rate(eGFR)， urine indexes including 24- hour urinary protein excretion and urine red blood cell(RBC) ， as well as the levels of inflammatory factors in serum including hypersensitive C- reactive protein(hs- CRP)， tumor necrosis factor- α(TNF- α) and interleukin- 6(IL- 6) in the two groups were compared. Results：The total effective rate was 97.67% in the observation group，higher than that of 81.40% in the control group(P＜ 0.05). After treatment，Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the score in the observation group was lower than that in the control group(P＜0.05). After treatment， the levels of hs- CRP， TNF- α and IL- 6 in serum， BUN and SCr in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above levels in the observation group were lower than those in the control group(P＜0.05)；24-hour urinary protein excretion and urine RBC in the two groups were decreased when compared with those before treatment(P＜0.05)，and 24- hour urinary protein excretion and urine RBC in the observation group were lower than those in the control group(P＜0.05)；eGFR in the two groups were increased when compared with those before treatment(P＜0.05)， and eGFR in the observation group was higher than that in the control group(P＜0.05). The incidence of adverse reactions was 11.63% in the observation group， lower than that of 30.23% in the control group(P＜0.05). Conclusion：The therapy of Yiqi Huoxue Qufeng prescription combined with western medicine for primary IgA nephropathy can effectively relieve the clinical symptoms of patients，improve the kidney function and reduce the levels of inflammatory factors，with good safety.