Abstract： Objective： To observe the clinical effect of Chinese medicine package combined with western medicine for acute cerebral infarction. Methods：A total of 98 cases of patients with acute cerebral infarction were selected and divided into the treatment group and the control group according to the random number table method，with 50 and 48 cases in each group respectively. The control group was treated with western medicine，and the treatment group was additionally treated with Chinese medicine package based on the treatment of the control group. Both groups were treated for 14 days. Chinese medicine syndrome scores，nerve function and muscle strength before and after treatment，as well as clinical effects in the two groups were compared between the two groups. Results：The total effective rate was 88.00% in the treatment group， higher than that of 68.75% in the control group(P＜0.05). After treatment， Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.05)， and the score in the treatment group was lower than that in the control group(P＜0.05). After treatment，scores of National Institutes of Health Stroke Scale(NIHSS) in the two groups were decreased when compared with those before treatment(P＜0.05)， and the NIHSS score in the treatment group was lower than that in the control group(P＜0.05). After treatment，muscle strength in the two groups was improved when compared with that before treatment(P＜0.05)，and the muscle strength in the treatment group was better than that in the control group(P＜0.05). Conclusion：Chinese medicine package combined with western medicine has a good curative effect in the treatment of acute cerebral infarction，which can improve clinical symptoms and nerve function，and help to restore the muscle strength.