夏橘化瘀胶囊对冠状动脉小血管病变患者心功能及心血管事件的影响
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R543.3+2

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潍坊市卫生健康委员会中医药科研项目(2021-2-004)


Effect of Xiaju Huayu Capsules on Heart Function and Cardiovascular Events of Patients with Coronary Microvascular Disease
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    摘要:

    目的:观察夏橘化瘀胶囊治疗冠状动脉小血管病变患者的临床疗效及其安全性。方法:选取冠状动脉小血管病变患者80 例,按随机数字表法分为2 组各40 例,对照组应用冠心病规范化药物治疗,观察组在对照组治疗方案的基础上加用夏橘化瘀胶囊治疗,治疗3 个月观察疗效。观察比较2 组患者左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD) 和左室重量指数(LVMI) 的变化,并随访3 个月内心血管事件发生情况,记录2 组不良反应发生情况。结果:治疗后,2 组LVEF、LVEDD、LVESD、LVMI 均较治疗前改善,组内治疗前后比较,差异均有统计学意义(P<0.05);且观察组较对照组改善更明显,治疗后组间比较,差异均有统计学意义(P<0.05);观察组心血管事件发生率明显低于对照组,差异有统计学意义(P<0.05);2 组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:夏橘化瘀胶囊可改善冠状动脉小血管病变患者的心功能及左室重构情况,减少心血管事件的发生率,且无明显不良反应。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Xiaju Huayu capsules on heart function and cardiovascular events of patients with coronary microvascular disease and its safety. Methods: A total of 80 cases of patients with coronary microvascular disease were selected and divided into two groups according to the random number table method , with 40 cases in each group. The control group was treated with standardized drugs for coronary heart disease, and the observation group was additionally treated with Xiaju Huayu capsules based on the treatment of the control group. Curative effect was observed during the three- month treatment. Changes in left ventricular ejection fraction(LVEF), left ventricular end diastolic diameter(LVEDD), left ventricular end systolic diameter(LVESD), and left ventricular mass index(LVMI) were observed and compared between the two groups. The incidences of cardiovascular events during three-month follow-up and adverse reactions in the two groups were recorded. Results:After treatment,LVEF,LVEDD,LVESD and LVMI in the two groups were improved when compared with those before treatment, differences being significant(P<0.05); the improvement in the observation group was more significant than that in the control group,differences being significant(P< 0.05). The incidence of cardiovascular events in the observation group was obviously lower than that in the control group, differences being significant(P<0.05);there was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P>0.05). Conclusion:Xiaju Huayu capsules can improve heart function and left ventricular remodeling in patients with coronary microvascular disease,reduce the incidence of cardiovascular events,and has no obvious adverse reactions.

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张华涛,陈婕,王霞,许军,李杰.夏橘化瘀胶囊对冠状动脉小血管病变患者心功能及心血管事件的影响[J].新中医,2022,54(6):68-71

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  • 在线发布日期: 2022-03-25
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