Abstract： Objective： To observe the clinical effect of Ditan tang on obstructive sleep apnea- hypopnea syndrome (OSAHS) of bingding of phlegm and stasis type and its effect on serum reduced glutathione(GSH) and malondialdehyde(MDA). Methods： A total of 60 patients with OSAHS were selected and divided into the control group and the experiment group according to the simple randomization method， with 30 cases in each group. The control group was treated with basic treatment only， and the experiment group was additionally treated with Ditan tang based on the treatment of the control group. After eight weeks of treatment， the clinical effects in the two groups were evaluated， and polysomnography monitoring， detection of levelsof oxidative stress markers and safety assessment were performed before and after treatment. Results：The total effective rate was 83.30% in the experiment group，higher than that of 10.00% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of oxygen desaturation index(ODI)，apnea- hypopnea index(AHI) and the lowest blood oxygen saturation(LSaO2) at night in the two groups(P＞0.05). After four and eight weeks of treatment，the levels of AHI and ODI in the experiment group were decreased when compared with those before treatment(P＜0.05)， the level of LSaO2 was increased(P＜0.05)； the levels of AHI and ODI in the experiment group were lower than those in the control group(P＜0.05)，the level of LSaO2 was higher；there was no significant difference being found in the comparison of levels of LSaO2，AHI and ODI in the control group before and after treatment(P＞0.05). Before treatment， there was no significant difference being found in the comparison of levels of MDA and GSH between the two groups(P＞0.05). After four and eight weeks of treatment，the level of MDA in the experiment group was decreased when compared with that before treatment(P＜0.05)，and the level of GSH was increased(P＜0.05)；the level of MDA in the experiment group was lower than that in the control group(P＜0.05)，and the level of GSH was higher(P＜0.05). There is no significant difference being found in the comparison of levels of MDA and GSH in the control group before and after treatment(P＞0.05). During treatment，no serious adverse reaction was found in both groups. Conclusion：The therapy of Ditan tanghas a definite curative effect on patients with OSAHS of binding of phlegm and stasis type， which can help improve the sleep and oxidative stress responses of patients， with no obvious adverse reaction.