Abstract： Objective： To observe the clinical effect of Chinese medicine point application combined with western medicine for mycoplasma pneumonia in children. Methods：A total of 60 cases of children with mycoplasma pneumonia were selected and divided into the control group and the observation group according to the random number table method，with 30 cases in each group. The control group was given routine western medicine，and the observation group was given Chinese medicine point application combined with western medicine. The disappearance time of cough， fever， asthma， and lung moist rale were compared between the two groups. Before and after treatment， Chinese medicine syndrome scores and levels of inflammatory factors including C- reactive protein(CRP) and procalcitonin(PCT) were detected in the two groups. Clinical effect and incidence of adverse reactions were evaluated. Results： The total effective rate was 96.67% in the observation group，higher than that of 76.67% in the control group，the difference being significant(χ 2=5.192，P=0.023). The disappearance time of cough， fever， asthma， and lung moist rale in the observation group were shorter than that in the control group(P＜0.05). After treatment， scores of main symptoms and secondary symptoms and total scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the three scores in the observation group were lower than those in the control group(P＜0.05). After treatment，levels of CRP and PCT in serum in the two groups were lower than those before treatment(P＜0.05)，and the two levels in the observation group were lower than those in the control group(P＜0.05). The incidence of adverse reactions in the observation group was lower than that in the control group(χ 2= 5.455， P=0.020). Conclusion： Chinese medicine point application combined with western medicine has a good curative effect and high safety in the treatment of mycoplasma pneumonia in children， and can effectively relieve their clinical symptoms and signs，and reduce levels of inflammatory factors and incidence of adverse reactions.