Abstract： Objective： To observe the clinical effect of Qingfei Tongqiao prescription combined with routine western medicine for chronic sinusitis(CRS) in children and its adverse reactions. Methods：A total of 62 cases of CRS children were selected as the research objects，and were divided into the treatment group and the control group according to the random number table method， with 32 and 30 cases in each group respectively. The control group was given routine western medicine treatment， and the treatment group was additionally treated with Qingfei Tongqiao prescription based on the treatment of the control group. Both groups were treated for two courses， with 14 days being a course. The changes in Chinese medicine syndrome scores and serum inflammatory factors including high- sensitivity C- reactive protein(hs- CRP) levels and neutrophil ratio before and after treatment as well as the clinical effects in the two groups were compared；the incidences of adverse reactions in the two groups were observed. Results：After treatment，the total clinical effective rate was 93.75% in the treatment group and 66.67% in the control group， the difference being significant(P＜0.05). After treatment， Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment，and the score in the treatment group was lower than that in the control group，differences being significant(P＜ 0.05). After treatment，the levels of hs- CRP and NEUT in serum in the two groups were decreased when compared with those before treatment，and the levels in the treatment group were lower than those in the control group，differences being significant(P＜0.05). After treatment，the incidence of adverse reactions was 6.25% in the treatment group and 10.00% in the control group， there being no significant difference(P＞0.05). Conclusion： The therapy of Qingfei Tongqiao prescription combined with routine western medicine for CRS is beneficial to improve curative effect and clinical symptoms of children， and reduce inflammatory responses，with a highly safe treatment plan.