Abstract： Objective： To observe the curative effect of the therapy of Kangfuxin liquid combined with omeprazole on active gastric ulcer and its effect on immune function and gastrointestinal hormones. Methods： A total of 90 patients with active gastric ulcer were divided into the observation group and the control group according to the random number table method，with 45 cases in each group. The control group was treated with omeprazole only，and the observation group was additionally treated with Kangfuxin liquid based on the treatment of the control group. The clinical effects and adverse reactions in the two groups were compared. Before and after treatment，the indexes of immune function and gastrointestinal hormones in the two groups were compared. Results：After treatment，the total clinical effective rate was 84.44% in the observation group，higher than that of 55.56% in the control group(P＜0.05). After treatment，the levels of CD3 +，CD4 +， CD4+/CD8+ in the two groups were increased when compared with those before treatment (P＜0.05)，and the levels of gastrin (GAS) and cholecystokininin (CCK) were decreased(P＜0.05)；after treatment，the levels of CD3+，CD4+，CD4+/CD8+ in the observation group were higher than those in the control group(P＜0.05)，and the levels of GAS and CCK were lower(P＜0.05). The incidence of adverse reactions was 13.33% in the observation group，lower than that of 40.00% in the control group(P＜ 0.05). Conclusion：The therapy of Kangfuxin liquid combined with omeprazole for active gastric ulcer can improve the clinical effects， immune function and levels of gastrointestinal hormones of patients， and reduce the adverse reactions in the treatment.