Abstract：Objective：To observe the clinical effect of Fengliao Changweikang tablets combined with famotidine on acute gastroenteritis and its effect on serum inflammatory factors. Methods：A total of 82 patients with acute gastroenteritis were divided into the treatment group and the control group according to the random number table method，with 41 cases in each group. The control group was treated with famotidine， and the treatment group was treated with Fengliao Changweikang tablets combined with famotidine. Before and after treatment， the changes of levels of serum inflammatory factors and hormone in the two groups were compared. The clinical effects and adverse reactions in the two groups were compared. Results：The total effective rate was 95.12% in the treatment group，higher than that of 78.05% in the control group(P＜ 0.05). After treatment， the serum levels of C-reactive protein(CRP)， interleukin- 1β(IL-1β)， interleukin- 17(IL-17) and interleukin-8(IL-8)，and the levels of pepsinogen I and pepsinogen II in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of gastrin and motilin were increased(P＜0.05)；after treatment，the serum levels of CRP，IL-1β，IL-17 and IL-8，and the levels of pepsinogen I and pepsinogen II in the treatment group were lower than those in the control group(P＜0.05)，and the levels of gastrin and motilin were higher(P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups(P＞0.05). Conclusion： The therapy of Fengliao Changweikang tablets combined with famotidine can significantly enhance the clinical effect on patients with acute gastroenteritis， improve the clinical symptoms， reduce the inflammation responses， and regulate the secretion of gastrointestinal hormones，with certain safety.