痰热清注射液对老年支气管哮喘患者动脉血气和血清炎症因子的影响
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R562.25

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Effect of Tanreqing Injection on Arterial Blood Gas and Serum Inflammatory Factors in Senile Patients with Bronchial Asthma
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    摘要:

    目的:观察痰热清注射液对老年支气管哮喘患者动脉血气和血清炎症因子的影响。方法:选取老年哮喘急性发作患者120 例,按随机数字表法分为观察组与对照组各60 例。对照组在常规治疗基础上予孟鲁司特钠治疗,观察组在对照组基础上予痰热清注射液治疗。比较2 组临床疗效、不良反应及治疗前后炎症因子、动脉血气指标。结果:观察组总有效率85.00%,明显高于对照组63.33%(P<0.05)。与同组治疗前比较,治疗后2 组白细胞介素-6(IL-6)、白细胞介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)、血二氧化碳分压(PaCO2)、血浆乳酸(Lac) 水平均降低(P<0.05),血氧分压(PaO2) 水平升高(P<0.05);与对照组治疗后比较,观察组治疗后IL-6、IL-4、TNF-α、PaCO2、Lac 水平均较低(P<0.05),PaO2 水平较高(P<0.05)。观察组心悸、恶心呕吐、喉咙刺激不良反应发生率分别为23.33%、16.67%、5.00%, 明显低于对照组的48.33%、36.67%、18.33%(P<0.05)。结论:痰热清注射液联合孟鲁司特钠治疗老年支气管哮喘,可明显提高治疗效果,降低血清炎症因子,改善动脉血气状态,减少不良反应。

    Abstract:

    Abstract:Objective:To observe the effect of Tanreqing injection on arterial blood gas and serum inflammatory factors in senile patients with bronchial asthma. Methods: A total of 120 cases of senile patients with acute attack of asthma were selected and divided into the observation group and the control group according to the random number table method,with 60 cases in each group. The control group was treated with montelukast sodium based on routine treatment, and the observation group was additionally treated with Tanreqing injection based on the treatment of the control group. Indexes of inflammatory factors and arterial blood gas before and after treatment as well as clinical effects and adverse reactions were compared between the two groups. Results: The total effective rate was 85.00% in the observation group, significantly higher than that of 63.33% in the control group(P<0.05). After treatment,levels of interleukin-6(IL-6),interleukin-4(IL-4), tumor necrosis factor-α(TNF-α),partial pressure of carbon dioxide(PaCO2) and plasma lactic acid(Lac) in the two groups were decreased when compared with those before treatment(P<0.05), and levels of blood oxygen partial pressure(PaO2) were increased(P<0.05). After treatment,levels of IL-6,IL-4,TNF-α,PaCO2 and Lac in the observation group were lower than those in the control group(P<0.05), and PaO2 level was higher(P<0.05). The incidences of palpitation, nausea and vomiting,throat irritation were 23.33%,16.67% and 5.00% respectively in the observation group,significantly lower than those of 48.33% , 36.67% and 18.33% in the control group(P<0.05). Conclusion: Tanreqing injection combined with montelukast sodium in the treatment of senile patients with bronchial asthma can effectively enhance curative effect,reduce serum inflammatory factors and adverse reactions,and improve arterial blood gas.

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魏琳莹,汪志平.痰热清注射液对老年支气管哮喘患者动脉血气和血清炎症因子的影响[J].新中医,2022,54(5):97-100

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  • 在线发布日期: 2022-03-10
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