Abstract： Objective： To observe the curative effect of Banxia Baizhu Tianma tang combined with irbesartan for hypertension and its effect on endothelial function. Methods： A total of 108 cases of patients with hypertension were randomly divided into the control group and the observation group， with 54 cases in each group. The control group was treated with irbesartan， and the observation group was treated with Banxia Baizhu Tianma tang combined with irbesartan. Changes in Chinese medicine syndrome scores， blood pressure， and endothelial function before and after treatment， as well as clinical effect and adverse reactions after treatment were compared between the two groups. Results： The total effective rate was 98.15% in the observation group， higher than that of 81.48% in the control group(P＜0.05). After treatment，Chinese medicine syndrome scores of dizziness and heavy-headedness，torpid intake and profuse phlegm，and oppression in the chest and lack of strength， as well as endothelin- 1(ET- 1) in the two groups were decreased when compared with those in the same group before treatment(P＜0.05)， and nitric oxide(NO) was increased(P＜0.05). After treatment，Chinese medicine syndrome scores of dizziness and heavy-headedness，torpid intake and profuse phlegm，and oppression in the chest and lack of strength，as well as endothelin-1(ET-1) in the observation group were lower than those in the control group(P＜0.05)，and NO was higher(P＜0.05). The incidence of adverse reactions was 5.56% in the observation group，lower than that of 20.37% in the control group(P＜0.05). Conclusion：In the treatment of patients with hypertension， Banxia Baizhu Tianma tang combined with irbesartan can significantly relieve dizziness， lack of strength， discomfort and other symptoms，lower blood pressure，improve vascular endothelial function and curative effect，and reduce drug adverse reactions.