Abstract：Traditional Chinese medicine has a unique curative effect on psoriasis.Traditional Chinese medicine monomers and effective components have achieved certain results in interfering with the proliferation and apoptosis of human immortalized keratinocytes(HaCaT)， regulating signal transduction pathway and regulating cellular immune function. Autor analyzes the monomer active components of traditional Chinese medicine acting on HaCaT cells by reading the representative literatures at home and abroad in recent 10 years. Common Chinese medicine monomers include saikosaponin， Polyphyllin Ⅰ， total glucosides of paeony， shikonin， matrine， paeonol， curcumin， ursolic acid， etc. Starting from the research progress of traditional Chinese medicine monomer on HaCaT cells， this paper expounds its corresponding mechanism，in order to provide reference for the research of traditional Chinese medicine monomer in the treatment of psoriasis.