Abstract： Objective： To explore the target and signal pathway of Sijunzi decoction in the treatment of Crohn disease. Methods：The disease target of Crohn disease was predicted by the National Biotechnology Information Center(NCBI)，and the main active components and target information of Sijunzi decoction were screened by TCMSP. Protein protein interaction (PPI) network was constructed by Cytoscape 3.7.2 software Bisogenet package，and ClusterProfiler R package was used for target gene ontology(GO) analysis and Kyoto Encyclopedia of genes and genomes(KEGG) pathway enrichment analysis. Results：It was predicted that frutinone A and 3β-acetoxyatractylolone，hederagenin，quercetin，kaempferol and other 98 active components mainly act on T cell surface antigen CD26(DPP4)， nitric oxide synthase 2(NOS2) and peroxisome proliferation activated receptor γ(PPARG) and other 27 Crohn disease target genes play a therapeutic role through 24 signal pathways such as interleukin(IL)- 17 signal pathway， tumor necrosis factor signal pathway and Leishmaniasis. Conclusion： Sijunzi decoction plays a role in the treatment of Crohn disease through multiple channels，links and targets.