Abstract：Objective：Based on Sirt mediated NF-κB/NLRP3 signaling pathway to explore the mechanism of astragaloside Ⅳ and curcumol on rats with chronic renal failure(CRF). Methods：The rat model of chronic renal failure was prepared，and the levels of serum creatinine(SCr) and 24 h urinary protein in each group(normal group，model group，astragalosideⅣgroup， Curcumol group， positive control group and Yiqi Huayu group) were detected before and after intervention. Nuclear transcription factor(NF-κB) was measured in each experimental group，nod like receptor protein 3(NLRP3)，interleukin-1β (IL-1β). The mRNA expression level of silent information regulatory factor 1(SIRT1) in renal tissue was detected by PCR and Western blot. Results： Compared with the normal group， the rats in the model group had symptoms such as decreased appetite，decreased activity，depressed spirit，reduced body mass and increased urine volume，and the above symptoms gradually aggravated； while the above symptoms were mild in the administration groups. After 4 weeks of modeling， the body mass of rats in each group was lower than that in the normal group(P＜0.05，P＜0.01). After administration，the body mass of rats in each group decreased compared with the normal group(P＜0.01). Compared with the model group，the body mass of each administration group increased(P＜0.05，P＜0.01).Before the intervention(after 4 weeks of modeling)，the SCr and 24 h urinary protein level of each model group was higher than that of the normal group(P＜0.01). After the intervention (12 weeks later)，the SCr and 24 h urinary protein level of astragaloside IV group，Curcumol group，positive control group and Yiqi Huayu group was higher than that of the normal group(P＜0.01)，but significantly lower than that of the model group (P＜0.01). Compared with the normal group，NF-κB、NLRP3、IL-1β in the model group was significantly higher(P＜0.01). The levels of serum NF-κB 、NLRP3 in astragaloside IV group，Curcumol group，positive control group and Yiqi Huayu group were significantly lower than those in model group(P＜0.05，P＜0.01). And the serum IL-1β in the positive control group and Yiqi Huayu group decreased significantly(P＜0.05， P＜0.01).Compared with the normal group， the relative expression of SIRT1 mRNA in the kidney of each model group decreased significantly(P＜0.05，P＜0.01).The expression of SIRT1 mRNA in each treatment group increased. Compared with the model group，the relative expression of SIRT1 mRNA in the Yiqi Huayu group increased significantly(P＜0.05). The positive expression of SIRT1 was mainly located in the nucleus and cytoplasm， showing brownish yellow granules. Compared with the normal group， the positive expression rate of SIRT1 in the model group decreased significantly(P＜0.01)； compared with the model group， the positive expression rate of SIRT1 in the administration group increased，and there was significant difference between the positive control group and the Yiqi Huayu group(P＜0.05，P＜0.01). Conclusion：Astragaloside IV and Curcumol can inhibit NF-κB by increasing the mRNA expression of SIRT1 in renal injury model rats. NLRP3 levels reduce the inflammatory factor IL-1β. It can improve the 24 h protein level and renal function of model rats，and the combined effect of the two is significant.