Abstract：This paper introduces the clinical experience of Professor JI Yunxi in treating refractory cough from spleen and kidney. Professor JI Yunxi believes that yang deficiency is the root of refractory cough which should be treated from the spleen and kidney. For patients in acute exacerbation of refractory cough，the combination of modified Xiaoqinglong tang and Zhisou powder is often applied， along with warming spleen and kidney as well as dissipating cold and dampness； for patients in chronic remission phase，modified Sishen Wuhui tang is applied to warm the kidney and supplement deficiency as well as raise yang and regulate qi. Thus，true yang is recovered，qi movement is unblocked and the cough is cured.