基于数据挖掘技术研究刘爱民辨治湿疹用药规律
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R758.23

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河南省中医药科学研究专项课题(2019JDZX038);河南省中医药科学研究专项课题(2019JDZX094);河南省中医药传承与创新人才 工程(仲景工程) 第二批中医药青苗人才项目(豫卫中医函[2021]16号)


Administration Rule of LIU Aimin in Treating Eczema According to Syndrome Differentiation Based on Data Mining Technology
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    摘要:

    目的:基于数据挖掘技术研究刘爱民教授治疗湿疹的用药规律。方法:运用中医传承辅助系统V2.5 对刘爱民教授门诊治愈的130 个湿疹医案(包含方剂298 首) 进行数据挖掘,得出药物频数及药物组合、药物性味归经、药物的关联度等用药规律。结果:数据挖掘结果显示,刘爱民治疗湿疹的用药规律:①药物以温性和寒性为主,二者频数比为1.28∶1;②药物以苦、辛、甘味药为主,占比达98.6%,且三种药味之比接近1∶1∶1;③药物归经以肺、脾、胃和膀胱经为主;④处方药味数多为12 味左右,药方精炼。使用频数为90 以上的药物有:黄柏、白鲜皮、防风、苍术、薏苡仁、陈皮、柴胡、甘草、麻黄、黄芪、茯苓、赤小豆、桂枝等。常用药物组合:①黄柏、白鲜皮;②黄柏、薏苡仁;③黄柏、苍术;④白鲜皮、苍术;⑤黄柏、防风等。常用药对:茯苓-当归,厚朴-干姜,茯苓-白扁豆,炒白术-麻黄,苍术-甘草等。核心药物组合有:牡蛎-柴胡-黄芪,黄芩-川牛膝-蜈蚣,炙甘草-甘草-薏苡仁,荆芥-茯苓-防风,白芍-黄柏-生姜等。新处方有:①牡蛎,柴胡,黄芪,砂仁,白扁豆;②黄芩,川牛膝,蜈蚣,山药,鸡内金;③炙甘草,薏苡仁,黄柏,大枣;④荆芥,茯苓,防风,制附子,麻黄;⑤白芍,黄柏,生姜,炙甘草,大枣等。结论:刘爱民教授治疗湿疹的用药规律体现其审湿求机、重视天人合一和脏腑辨证的学术思想。

    Abstract:

    Abstract: Objective: To study the administration rule of Prof. LIU Aimin in treating eczema according to syndrome differentiation based on data mining technology. Methods:Data mining was performed on 130 cases with eczema,including 298 prescriptions, cured by Prof. LIU in outpatient department by TCM Inheritance Assistant System V2.5, and the frequency of Chinese herbs,herbal combinations,the natures,flavors and channel entry of herbs as well as the correlation of herbs were obtained. Results:Data mining results showed that Prof. LIU's administration rules in treating eczema were as follows. ①In terms of natures, the main herbs were warm and cold, and the frequency ratio of them was 1.28∶ 1. ②In terms of flavors,the main herbs were bitter,bitter and sweet,accounting for 98.6%,and the ratio of the flavors was close to 1∶ 1∶ 1. ③In terms of channel entry, the herbs entered the channels of lung, spleen, stomach and bladder. ④The number of herbs in the prescriptions was usually around 12,and the prescriptions were succinct. Herbs with a frequency of more than 90 were Cortex Phellodendri Chinensis,Cortex Dictamni,Radix Saposhnikoviae,Rhizoma Atractylodis,Semen Coicis, Pericarpium Citri Reticulatae, Radix Bupleuri, Radix et Rhizoma Glycyrrhizae, Herba Ephedrae, Radix Astragali, Poria,Semen Phaseoli,Ramulus Cinnamomi. The common herbal combinations were:①Cortex Phellodendri Chinensis and Cortex Dictamni, ② Cortex Phellodendri Chinensis and Semen Coicis, ③ Cortex Phellodendri Chinensis and Rhizoma Atractylodis,④Cortex Dictamni and Rhizoma Atractylodis,⑤Cortex Phellodendri Chinensis and Radix Saposhnikoviae. The common herbal pairs were Poria and Radix Angelicae Sinensis,Cortex Magnoliae Officinalis and Rhizoma Zingiberis,Poria and Semen Lablab Album, dry- fried Rhizoma Atractylodis Macrocephalae and Herba Ephedrae, Rhizoma Atractylodis and Radix et Rhizoma Glycyrrhizae. The core herbal combinations were Concha Ostreae- Radix Bupleuri- Radix Astragali,Radix Scutellariae- Radix Cyathulae- Scolopendra, Radix et Rhizoma Glycyrrhizae Praeparata cum Melle- Radix et Rhizoma Glycyrrhizae- Semen Coicis,Herba Schizonepetae- Poria- Radix Saposhnikoviae,Radix Paeoniae Alba- Cortex Phellodendri Chinensis- Rhizoma Zingiberis Recens. The new prescriptions were: ①Concha Ostreae, Radix Bupleuri, Radix Astragali, Fructus Amomi and Semen Lablab Album;②Radix Scutellariae,Radix Cyathulae,Scolopendra,Rhizoma Dioscoreae and Endothelium Corneum Gigeriae Galli; ③ Radix et Rhizoma Glycyrrhizae Praeparata cum Melle, Semen Coicis, Cortex Phellodendri Chinensis and Fructus Jujubae;④Herba Schizonepetae,Poria,Radix Saposhnikoviae,Radix Aconiti Lateralis Praeparata and Herba Ephedrae;⑤Radix Paeoniae Alba,Cortex Phellodendri Chinensis,Rhizoma Zingiberis Recens,Radix et Rhizoma Glycyrrhizae Praeparata cum Melle and Fructus Jujubae. Conclusion: Prof. LIU's administration rule in treating eczema reflects his academic thought of examining dampness and seeking the pathogenesis,as well as attaching importance to the unity of nature and human and syndrome differentiation of zang-fu organs.

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徐胜东,赵巍,刘占河,指导:刘爱民.基于数据挖掘技术研究刘爱民辨治湿疹用药规律[J].新中医,2022,54(4):183-188

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  • 在线发布日期: 2022-02-24
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