Abstract：Objective：To observe the clinical effect of Xiaobailing tang combined with 308 nm excimer laser on vitiligo. Methods：A total of 82 cases of patients with vitiligo were randomly divided into the observation group and the control group， with 41 cases in each group. The control group was treated with 308 nm excimer laser， and the observation group was additionally treated with Xiaobailing tang based on the treatment of the control group. Both groups were treated for 12 weeks. Clinical effects were observed and compared between the two groups. Chinese medicine syndrome scores and Vitiligo Area Scoring Index(VASI) at different time points before and after treatment were compared between the two groups. Results： The total effective rate was 97.6% in the observation group and 87.8% in the control group，the difference being significant (P＜0.05). Chinese medicine syndrome scores one month and three months after treatment in the two groups were decreased when compared with those before treatment(P＜0.05)，and the scores at two time points after treatment in the observation group were lower than those in the control group(P＜0.05). Scores of VASI one month and three months after treatment in the two groups were decreased when compared with those before treatment(P＜0.05)，and the scores at two time points after treatment in the observation group were lower than those in the control group(P＜0.05). Conclusion：The therapy of Xiaobailing tang combined with 308 nm excimer laser in the treatment of vitiligo can effectively improve effective rate of treatment，relieve clinical symptoms，and reduce vitiligo area and skin lesion degree.