Abstract： Objective： To observe the clinical effect of Wenshen Naqi tang combined with aerosol inhalation with budesonide for bronchial asthma in children and its effect on inflammatory factors. Methods：A total of 118 cases of children with bronchial asthma were divided into the control group and the study group according to the random number table method，with 59 cases in each group. Both groups were given routine treatment for anti-infection，relieving wheezing and soothing coughs； the control group was additionally treated with aerosol inhalation with budesonide， and the study group was additionally treated with Wenshen Naqi tang based on the treatment of the control group. The clinical effects and the alleviation time of related symptoms and signs in the two groups were observed and compared. Before and after treatment， the levels of interleukin-2(IL-2)，interleukin-6(IL-6)，interleukin-8(IL-8) and tumor necrosis factor-α(TNF-α) in serum in the two groups were compared and analyzed. Results：The total effective rate was 98.3% in the study group and 84.7% in the control group，the difference being significant(P＜0.05). After treatment，the alleviation time of asthma，rales and cough in the study group was shorter than that in the control group，the difference being significant(P＜0.05). After treatment，the IL-2 levels in the two groups were increased when compared with those before treatment，and the levels of IL-6，IL-8 and TNF-α were decreased(P＜0.05)；the improvement of indexes in the study group was more significant than that in the control group(P＜0.05). Conclusion： The application of aerosol inhalation with budesonide combined with Wenshen Naqi tang for bronchial asthma in children can significantly enhance clinical effects， quickly relieve symptoms， and effectively improve levels of inflammatory factors in serum.