Abstract： Objective： To observe the clinical effect of Bushen Jiegu prescription combined with internal fixation with interlocking intramedullary nail for nonunion after limb fracture. Methods：A total of 82 cases of patients with nonunion after limb fracture were selected and divided into the control group and the observation group according to the random number table method，with 41 cases in each group. After internal fixation with interlocking intramedullary nail，the control group was given antibiotics for routine treatment， and the observation group was additionally treated with Bushen Jiegu prescription based on the treatment of the control group. Before operation and three months after operation， the levels of alkaline phosphatase(ALP) in serum in the two groups were compared. Before operation and nine months after operation，the scores of fracture callus in the two groups were compared. The fracture healing time，the healing rate of nonunion，and the clinical effects in the two groups were compared. Results：Three months after operation，the ALP levels in serum in the two groups were increased when compared with those before operation(P＜0.05)，and the ALP level in serum in the observation group was higher than that in the control group(P＜0.05). Nine months after operation， the scores of fracture callus in the two groups were increased when compared with those before operation(P＜0.05)， and the score of fracture callus in the observation group was higher than that in the control group(P＜0.05). The fracture healing time was(6.51±1.05) months in the observation group，shorter than that of(7.82±1.15) months in the control group(P＜0.05). Nine months after operation，the healing rate of nonunion was 95.12% in the observation group，higher than that of 78.05% in the control group(P＜0.05). The clinical effect in the observation group was better than that in the control group(P＜0.05). Conclusion： Bushen Jiegu prescription combined with internal fixation with interlocking intramedullary nail for nonunion after limb fracture can shorten the fracture healing time and improve the healing rate of nonunion.