Abstract： Objective： To observe the clinical effect of the therapy of modified Changhua prescription combined with western medicine on chronic atrophic gastritis(CAG) complicated with intestinal metaplasia(IM). Methods： A total of 126 CAG patients complicated with IM were selected and divided into the control group and the study group according to the random number table method， with 63 cases in each group. The control group was treated with western medicine， and the study group was additionally treated with modified Changhua prescription based on the treatment of the control group. Both groups were treated for three months. The clinical effects and adverse reactions in the two groups were compared；before and after treatment， the scores of gastric mucosa indexes， pepsinogen ratio(PGR) and levels of gastrin(GAS)， tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in the two groups were compared. Results：The total effective rate was 92.06% in the study group， higher than that of 77.78% in the control group(P＜0.05). After treatment， the scores of mucosa inflammation， inflammatory activity， glandular atrophy and IM in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above scores in the study group were lower than those in the control group(P＜ 0.05). After treatment， the PGR values in both groups were increased when compared with those before treatment(P＜ 0.05)， and the levels of GAS， TNF-α and IL-6 were decreased(P＜0.05)；the PGR value in the study group was higher than that in the control group(P＜0.05)， and the levels of GAS， TNF- α and IL- 6 were lower(P＜0.05). During treatment， no obvious adverse reactions were found in both groups. Conclusion：The therapy of modified Changhua prescription combined with western medicine can effectively alleviate the clinical symptoms of CAG complicated with IM patients， improve the pathology of gastric mucosa， and reduce the levels of inflammatory factors， with high safety.