Abstract： Objective： To observe the clinical effect of Qizhi Weitong granules combined with routine treatment in western medicine for epigastric pain with qi stagnation in the liver and the stomach syndrome. Methods：A total of 120 cases of patients with epigastric pain were divided into the control group and the observation group according to the random number table method，with 60 cases in each group. The control group was treated with routine treatment in western medicine，and the observation group was additionally treated with Qizhi Weitong granules based on the treatment of the control group. Both groups were treated with four weeks. The clinical effects， and the scores of qi stagnation in the liver and the stomach syndrome and 36-Item Short Form Health Survey(SF-36) in the two groups were compared. Results：The total effective rate was 96.67% in the observation group and 83.33% in the control group， the difference being significant(P＜0.05). After treatment， the scores of Chinese medicine syndromes including distending and pain in gastric cavity， sighing frequently， poor appetite，mental depression and restless sleep at night in the two groups were decreased when compared with those before treatment(P＜0.05)，and the symptom scores in qi stagnation in the liver and the stomach syndrome in the observation group were lower than those in the control group(P＜0.05). After treatment，the scores of physiological role，physiological function， social function， emotional function， physical pain， vitality and mental health in SF- 36 in the two groups were significantly increased when compared with those before treatment(P＜0.05)，and the above scores in the observation group were higher than those in the control group(P＜0.05). Conclusion： Based on routine treatment in western medicine， the additional application of Qizhi Weitong granules has a definite curative effect in treating epigastric pain with qi stagnation in the liver and the stomach syndrome，and can effectively improve Chinese medicine syndromes and quality of life，whose effect is better than that of simple routine treatment in western medicine.