Abstract： Objective： To observe the effect of Shenyan Kangfu tablets combined with compound α- ketonic acid on kidney function， proteinuria and inflammatory response in senile patients with diabetic nephropathy. Methods： A total of 82 cases of senile patients with diabetic nephropathy were selected and divided into the control group and the observation group according to the odd and even number of admission date，with 41 cases in each group. Both groups were given routine treatment including controlling the diet， correcting water and electrolyte disorder and reducing blood glucose； the control group was additionally treated with compound α-ketonic acid tablets，and the observation group was additionally treated with Shenyan Kangfu tablets based on the treatment of the control group. Both groups were treated for three months. Before and after treatment， the levels of urea nitrogen(BUN)， serum creatinine(SCr)， 24- hour urine protein excretion， hemoglobin (Hb)，serum albumin，tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in the two groups were compared. Results： After treatment，the levels of BUN，SCr，TNF-α and IL-6 as well as 24-hour urine protein excretion in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of BUN，SCr，TNF-α and IL-6 as well as 24-hour urine protein excretion in the observation group were lower than those in the control group(P＜0.05). The levels of Hb and serum albumin in the two groups were increased when compared with those before treatment(P＜0.05)，and the levels of Hb and serum albumin in the observation group were higher than those in the control group(P＜0.05). Conclusion： The therapy of Shenyan Kangfu tablets combined with compound α- ketonic acid for senile diabetic nephropathy can inhibit inflammatory response，reduce proteinuria and protect kidney function.