Abstract：Objective：To observe the clinical effect of Tongxuan Lifei capsules combined with routine western medicine for acute bronchitis. Methods：A total of 92 cases of patients with acute bronchitis were selected and randomly divided into the control group and the observation group，with 46 cases in each group. The control group was treated with budesonide， ipratropium bromide and terbutaline，and the observation group was additionally treated with Tongxuan Lifei capsules based on the treatment of the control group. Symptom scores，the disappearance time of symptoms and signs(fever，wheezing， cough， wheezing rales)， hospitalization time， indexes of the lung function[forced vital capacity(FVC)， forced expiratory volume in one second(FEV1)， (FEV1/FVC)]， levels of inflammatory factors[C- reactive protein(CRP)， interleukin- 6(IL- 6)， interleukin-8(IL-8)] and total clinical effects were compared between the two groups. Results：The total effective rate was 95.65% in the observation group， and 78.26% in the control group， the difference being significant(P＜0.05). After treatment，scores of wheezing and panting，cough and expectoration，vexation and agitation，red tongue and yellow fur， and slippery and rapid pulse in the two groups were decreased when compared with those before treatment(P＜0.05)，and each score in the observation group was lower than that in the control group(P＜0.05). After treatment，the disappearance time of symptoms and signs and hospitalization time in the observation group were shorter than those in the control group， differences being significant(P＜0.05). After treatment， indexes of FVC， FEV1， and FEV1/FVC in the two groups were increased when compared with those before treatment(P＜0.05)，and each index in the observation group was higher than that in the control group(P＜0.05). After treatment，levels of CRP，IL-6 and IL-8 in serum in the two groups were decreased when compared with those before treatment(P＜0.05)，and each level in the observation group was lower than that in the control group(P＜0.05). Conclusion： The therapy of Tongxuan Lifei capsules combined with routine western medicine for acute bronchitis can improve the clinical effect and the lung function， and effectively relieve clinical symptoms and inflammatory responses.